Lymphocyte trafficking and IBD: Migration into the gut

Chemokines and IBD

  • Chemokines are a family of small proteins that play an important role in recruitment and activation of lymphocytes1,2
  • Biological effects of chemokines result from binding to chemokine receptors1,2
  • Several chemokines and their receptors play a role in homeostasis of mucosal immunity and pathogenesis of IBD. Some examples include2:
    • CCL20-CCR6
    • CCL25-CCR9
    • CCL28-CCR10

α4β7-MAdCAM-1 and IBD

  • α4β7-MAdCAM-1 interactions likely mediate selective lymphocyte trafficking to normal GI mucosa and gut-associated tissues3
  • The expression of the adhesion molecule MAdCAM-1 is increased at sites of IBD3
  • As such, the α4β7 and MAdCAM-1 adhesion mechanism may be closely involved in lymphocyte trafficking to the site of inflammation in the gut3

Lymphocyte trafficking and IBD

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  1. Yoshie O, Imai T, Nomiyama H. Chemokines in immunity. Adv Immunol. 2001;78:57-110.

  2. Nishimura M, Kuboi Y, Muramoto K, Kawano T, Imai T. Chemokines as novel therapeutic targets for inflammatory bowel disease. Ann N Y Acad Sci. 2009;1173:350-356.

  3. Briskin M, Winsor-Hines D, Shyjan A, et al. Human mucosal address in cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol. 1997;151(1):97-110.

  4. Janeway CA Jr, Travers P, Walport M, Shlomchik MJ. Immunobiology: The Immune System in Health and Disease. 6th ed. New York, NY: Garland Science Publishing; 2005.

  5. Stedman’s Medical Dictionary. 27th ed. New York, NY: Lippincott Williams & Wilkins; 2000.

  • Chemokine: small chemoattractant protein that stimulates the migration and activation of cells, especially phagocytic cells and lymphocytes4

  • Lymphocytes: a class of white blood cells that bear variable cell-surface receptors for antigen; there are 2 main classes—B cells and T cells—which mediate humoral and cell-mediated immunity, respectively4

  • Mucosal: pertaining to the mucous tissue lining various tubular structures, consisting of epithelium, lamina propria, and in the digestive tract, a layer of smooth muscle5

  • Adhesion molecule: mediates the binding of one cell to other cells or to extracellular matrix proteins4

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